Quadrupole Time Of Flight – Mass spectrometry

Agilent 6545 XT QTOF-MS offers a suitable improved resolution for the measurement of biomolecules up to 30000 m/z and accurate mass measurement up to low ppm levels. Intact mass analysis and peptide mapping studies are routinely performed using this equipment.

Model

Agilent 6545 XT QTOF-MS

Assays

  • Antibody characterization studies: Intact mass, light chain and Heavy chain analysis
    Antibody Drug Conjugate (ADC) and Drug Antibody Ratio (DAR) analysis
    Host Cell Protein studies for assessing process specific impurities in Biopharmaceuticals
    Peptide mapping studies, N/C-Terminal sequencing, Di-sulphide mapping
    Site specific glycosylation and Post Translational Modifications (PTMs) studies, Lysine truncation, proline amidation, Critical Quality Attributes (CQA) monitoring.

Resources